Description
Product Characteristics: The clone CB3-1, a mouse monoclonal antibody recognizes a 37-39 kD type I integral membrane protein known as CD79. CD79 is a heterodimeric molecule comprised of an alpha-chain (CD79a) and a beta-chain (CD79b). It is noncovalently associated with the CD79a and cell surface IgM to form the B-cell receptor (BCR) complex. CD79b expression is exclusive to B lymphocytes and B cell lymphomas. It can be expressed either in the cytoplasm or on the cell surface depending on the maturation state of the B cells. The CD79 receptor complex triggers numerous signaling pathways to mediate B cell development, maintenance, and activation.
Target Information: The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]